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Sunday, March 13, 2011

Children and Leigh's Disease

Leigh’s Disease is most often passed to a child through autosomal recessive transmission.  This means the disease is not dominate, therefore you need both parents to be a carrier, or to be affected, for a child to get it.  If both parents are carriers, Rr, then they have a 25% chance of having an unaffected child, a 25% chance of having an affected child, and a 50% chance of having a carrier child. Use the diagram below as a visual aid to better understand what I just explained.
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If both parents are unaffected by Leigh’s Disease, RR, there is a 100% chance that their children will also be unaffected.   If one parent is affected, rr, and one parent is a carrier, Rr, there is a 50% chance that their child will be affected by Leigh’s Disease, and a 50% chance it will be a carrier.

3 comments:

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